Idiopathic Multicentric Castleman’s Disease with Normal Interleukin-6 Levels
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چکیده
Multicentric Castleman’s disease (MCD) is a rare systemic lymphoproliferative disorder characterised by polylymphadenopathy, B-symptoms and classical lymph node histological findings. Hypercytokinemia, particularly interleukin-6 (IL-6), secondary to human herpes virus-8 (HHV-8) infection is key to the pathogenesis of MCD. However, MCD can occur independent of HHV-8 an entity known as idiopathic MCD (iMCD) [1]. Uncommonly, a subset of patients can have normal IL-6 levels thus suggesting that other cytokines and pathways contribute to pathogenesis of iMCD.
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Idiopathic Multicentric Castleman’s Disease with Normal Interleukin-6 Levels
Multicentric Castleman’s disease (MCD) is a rare systemic lymphoproliferative disorder characterised by polylymphadenopathy, B-symptoms and classical lymph node histological findings. Hypercytokinemia, particularly interleukin-6 (IL-6), secondary to human herpes virus-8 (HHV-8) infection is key to the pathogenesis of MCD. However, MCD can occur independent of HHV-8 an entity known as idiopathic...
متن کاملIdiopathic Multicentric Castleman’s Disease with Normal Interleukin-6 Levels
Multicentric Castleman’s disease (MCD) is a rare systemic lymphoproliferative disorder characterised by polylymphadenopathy, B-symptoms and classical lymph node histological findings. Hypercytokinemia, particularly interleukin-6 (IL-6), secondary to human herpes virus-8 (HHV-8) infection is key to the pathogenesis of MCD. However, MCD can occur independent of HHV-8 an entity known as idiopathic...
متن کاملA relapsing inflammatory syndrome and HHV-8.
to the editor: The case of human herpesvirus 8 (HHV-8) reported by Dagna et al. (July 14 issue)1 is considered to be distinct from HHV-8–associated multicentric Castleman’s disease owing to the absence of typical histologic findings and elevated plasma levels of interleukin-6. The histopathology of HHV-8–associated multicentric Castleman’s disease is variable, as compared with the classic descr...
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Castleman’s disease, an atypical lymphoproliferative disorder, can be classified into 2 types: hyaline-vascular and plasma cell types according to the histologic features of the affected lymph nodes. The plasma cell type is frequently associated with systemic manifestations and is often refractory to systemic therapy including corticosteroids and chemotherapy, particularly in multicentric form....
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